Antibody Engineering

Advancing antibody function through smart design.

Techniques like Fc modification, glycoengineering, and humanization unlock therapeutic potential while minimizing immunogenicity and maximizing consistency across patient populations.

Fusion Antibodies builds smarter biologics through precision engineering—designed for therapeutic impact.

• Humanization: Converts non-human sequences into human frameworks to reduce immunogenicity.
• Affinity Maturation: Enhances target binding via rational mutagenesis.
• Specificity Tuning: Minimizes off-target effects for improved selectivity.
• Isotype Switching: Adjusts Fc isotype to modulate immune effector functions.

• Fc Engineering: Extends half-life and tailors for ADCC/CDC activity.
• Bispecific & Multispecific Design: Targets multiple epitopes or pathways simultaneously.
• Cytokine/Peptide Fusion: Fc fusion boosts stability, half-life, and immune engagement.
• Fragment Engineering: scFv, Fab, and nanobody formats for enhanced tissue penetration.
• Multivalent Constructs: Increases avidity and receptor clustering.

• Deimmunization: Removes T-cell epitopes to reduce ADA risk—available standalone or within humanization.
• Aggregation / Fragmentation Resistance: Introduces mutations to prevent aggregation and fragmentation.
• Glycoengineering: Modifies glycosylation to fine-tune effector functions and reduce immunogenicity.

• Expression Optimization: Codon and sequence tuning for high-yield production.
• Thermostability Engineering: Enhances shelf-life and formulation robustness.
• Purification Tag Design: Streamlines downstream processing and QC.

• ADC Engineering: Enables site-specific payload conjugation for targeted delivery.
• Checkpoint Modulation: Designs antibodies to block or activate immune checkpoints using off-patent or custom sequences.
• Receptor Signaling Modulation: Adjusts valency and orientation for agonist or antagonist activity.