Fc Engineering for Function, Stability, and Clinical Success
Enhance effector function, extend half-life or silence activity with Fc region modifications designed by our expert team.
Fc Engineering for Function, Stability, and Clinical Success
Enhance effector function, extend half-life or silence activity with Fc region modifications designed by our expert team.
Why FC Engineering Matters
The Fc (Fragment crystallizable) region governs critical antibody properties, influencing immune system engagement, recycling via FcRn, and product stability. Tailoring this region enables developers to fine-tune the antibody's function to align with their therapeutic goal.
Whether your program requires enhanced ADCC, silencing of immune activity, or extended serum persistence, our team delivers precision-engineered Fc variants designed to meet regulatory and clinical expectations.
Custom Modifications to Suit your Application
| Engineering Goal | Purpose |
|---|---|
| Effector Function Enhancement | To increase the antibody's ability to recruit immune cells and trigger immune responses such as ADCC (Antibody-Dependent Cellular Cytotoxicity) and CDC (Complement-Dependent Cytotoxicity) |
| Effector Silencing | To reduce or eliminate interaction with Fcγ receptors and complement proteins, minimizing immune activation |
| Half-Life Extension | To prolong the antibody's circulation time by increasing its interaction with the neonatal Fc receptor (FcRn). |
| Fc-Fusion Constructs | To fuse the Fc region with biologically active proteins (e.g., cytokines, ligands, or enzymes), thereby combining their activity with the favorable pharmacokinetics of antibodies |
| Manufacturability optimization | To improve expression, stability, solubility, and reduce aggregation or degradation during production and storage |
Our Fc Engineering Approach
- Goal DefinitionWe work with you to define the optimal Fc profile based on therapeutic indication and mechanism of action.
- Design & In Silico EvaluationSelection of optimal Fc mutations based on structural knowledge and literature-supported variants.
- Expression & ScreeningFc variants produced in mammalian cells and screened for activity, stability, and yield.
- Biophysical & Functional CharacterisationComprehensive evaluation including ADCC, CDC, FcRn binding, and thermal stability.
- Developability Risk AssessmentEarly identification of potential aggregation, clearance, and manufacturability issues to streamline downstream development.
Tell us what you’re working on.
Share the useful starting details and your enquiry will be sent securely to Fusion’s scientific team.